Mechanisms of hyporeactivity in mice after injection of lysed erythrocyte antigen

Autor: Anfalova, T. V., Pevnitskii, L. A.
Zdroj: Bulletin of Experimental Biology and Medicine; March 1979, Vol. 87 Issue: 3 p245-249, 5p
Abstrakt: A state of specific hyporeactivity to sheep's red cells (SRBC) was induced in mice by injection of hemolyzed SRBC. Blocking serum factor in these mice was shown not to be identical in the character of its action with antired-cell antibodies, but to be probably an antigen-antibody complex. After combined injection of hemolyzed SRBC and cyclophosphamide (CP) into mice production of blocking serum factor was suppressed but the reactivity of the mice to SRBC was considerably reduced. It is suggested that in this case inactivation of the immunocompetent cells took place through the combined action of CP and SRBC antigen in a nonimmunogenic form.
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