Formation of complexes of epileptic activity in the cerebral cortex under the influence of a determinant focus induced by acetylcholine

Autor: Kryzhanovskii, G. N., Makul'kin, R. F., Shandra, A. A., Okhtishkin, N. E.
Zdroj: Bulletin of Experimental Biology and Medicine; February 1979, Vol. 87 Issue: 2 p92-96, 5p
Abstrakt: Foci of enhanced excitability, with independent discharge patterns, were created by means of weak solutions of strychnine and penicillin in cats. The creation of a hyperactive focus by means of acetylcholine (ACh) and neostigmine led initially to an increase in the amplitude and frequency of the paroxysmal discharges in the nearest foci of activity, and later in foci remote from the hyperactive focus. Qualitative changes subsequently developed in the pattern of activity of the strychnine and penicillin foci (with the appearance of ACh-activity in them) and a single functional complex of foci with the same discharge pattern as the ACh-focus was formed. The latter thus plays the role of determinant structure. Inhibition of the activity of the determinant focus was followed by disappearance of ACh-activity in the other foci, restoration of original (penicillin or strychnine) activity in them, and destruction of the epileptic complex.
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