| Autor: |
Polunin, B. A., Tumanov, V. P., Avrutskii, M. Ya. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; December 1979, Vol. 88 Issue: 6 p1484-1487, 4p |
| Abstrakt: |
In 27 experiments on rabbits the cerebral cortex was investigated after ischemia for 15 min associated with controlled hypotension. The aim of the investigation was to test the efficacy of Nootropil and Contrykal as drugs for the treatment of posthypoxic cerebral edema. The effects of treatment were judged on the basis of light- and electron-microscopic observations. Nootropil had a favorable effect on the ultrastructure of intraneuronal organelles (mitochondria, lysosomes, ribosomal apparatus, nuclear membrane, and so on). During treatment with Nootropil and Contrykal the changes in the microcirculatory system after hypoxia showed signs of compensation and were reversible. The manifestations of posthypoxic cerebral edema were less marked. The efficacy of the suggested scheme of treatment is attributed to the normalizing effect of Nootropil on metabolic and intracellular repair processes in neurons and cells belonging to the microcirculatory system and also to the direct action of Contrykal on local capillary permeability factors. |
| Databáze: |
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