The use of mini pigs — A new kind of experimental animal — To study the embryotropic action of phenazepam

Autor: Lyubimov, B. I., Smol'nikova, N. M., Strekalova, S. N., Boiko, S. S., Yavorskii, A. N., Dushkin, V. A., Poznakhirev, P. R.
Zdroj: Bulletin of Experimental Biology and Medicine; November 1979, Vol. 88 Issue: 5 p1290-1292, 3p
Abstrakt: Experiments on a Siberian breed of mini pigs showed that phenazepam, in a dose of 1 mg/kg internally throughout the period of organogenesis, has neither embryotoxic nor teratogenic action. Parallel determinations of the blood level of the compound were made in pregnant animals. It can be concluded from the results of this investigation that mini pigs are a promising species with which to test the embryotropic activity of drugs.
Databáze: Supplemental Index