| Abstrakt: |
The transplacental carcinogenic action of various known carcinogens—ethylnitrosourea (ENU), methylnitrosourea (MNU), dimethylbenzanthracene (DMBA), and benzo(a)pyrene (BP)—was investigated in experiments on rabbits. ENU was found to have the strongest carcinogenic activity, with a well-marked neurotropic effect. It was shown at the same time that the relative affinity for various tissues that is characteristic of the action of certain carcinogens on the adult organism is not always manifested in transplacental carcinogenesis. The study of the effect of various modifying factors (organ-specific immunization, chronic peripheral nerve stimulation, injection of MNU) on the realization of transplacental carcinogenesis showed that their postnatal administration mainly stimulates the development of peripheral nerve tumors in the progenies (MNU inhibits tumor development). |
Full text from SpringerLink