| Autor: |
Gushchin, I. S., Kaminka, M. E., Deryugin, I. L. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; October 1978, Vol. 86 Issue: 4 p1367-1370, 4p |
| Abstrakt: |
Phenothiazine (chloropromazine and promethazine) and antihistamine quinuclidine derivatives [Phencarol, quinuclidyl-d-di-(o-tolyl) carbinol, quinuclidyl-3-di-(o-methoxyphenyl) carbinol hydrochloride (QMCH)], in doses below those liberating histamine, inhibited histamine liberation from the mast cells of rats induced by compound 48/80. QMCH inhibited histamine liberation induced by selective liberators (compound 48/80, MCD-peptide, and specific antigen), but potentiated histamine liberation induced by nonselective liberators (Triton X-100 and chlorpromazine). The inhibitory action of QMCH on histamine liberation induced by compound 48/80 increased for 1 min and was reversible. The inhibitory effect of all the compounds tested was reduced to some extent in the presence of glucose. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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