| Autor: |
Frol'kis, V. V., Valueva, G. V., Verzhikovskaya, N. V. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; August 1978, Vol. 86 Issue: 2 p981-984, 4p |
| Abstrakt: |
Age differences in interaction between the hypothalamic-hypophyseal system and the thyroid gland were studied with consideration to both direct and feedback control. In old age significant disturbances affect both direct and feedback components of this system; the sensitivity of thyroid tissue to TSH and of the hypothalamus and pituitary to the action of T4 is increased. The increased sensitivity of the hypothalamic-hypophyseal system to T4 is largely determined by activation of the deiodination of T4 by the adenohypophysis. The reactivity of the thyroid gland and hypothalamic-hypophyseal complex to the corresponding factors is reduced. |
| Databáze: |
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| Externí odkaz: |
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