| Abstrakt: |
Estradiol(E2)-binding proteins of the liver cytosol of sexually mature female and male rats, mice, guinea pigs, and rabbits were investigated by gel-filtration on Sepharose 6B columns. Components with Stokes' radii (a) of 6–7 and 2.5 nm, forming specific, stable complexes with E2, were found in the liver of female rats and of male and female mice. Components with values of (a) of 6–7, 2.5, and under 2.0 nm, specifically binding E2, were discovered in the liver of male rats and male and female guinea pigs. Complexes of E2 with components with (a) values of 6–7 and under 2.0 nm were relatively stable, whereas the complex of E2 with the component witha=2.5 nm could dissociate completely in 45 min. It is suggested that at least some of the components of these heterogeneous populations of E2-binding proteins may participate in the reception of the estrogen signal by the liver. |
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