Inhibitors of trypsin-like proteolytic enzymes as substances preventing the development of secondary necrosis in burn wounds

Autor: Muzykant, L. I., Zaets, T. L., Dolgina, M. I., Kotkina, T. I., Nosova, I. M., Kaem, R. I., Panova, Yu. M., Kerova, A. I.
Zdroj: Bulletin of Experimental Biology and Medicine; September 1977, Vol. 84 Issue: 3 p1257-1261, 5p
Abstrakt: A biochemical, histological, and histochemical study was made of the effect of contrykal, an inhibitor of proteolytic enzymes, on the healing of experimental burn wounds in rats. Healing of burn wounds (flame burns covering 20% of the body surface) in animals untreated with contrykal was found to be accompanied by the development of secondary necrosis, by a marked inflammatory reaction, and by increased activity of certain proteases and peptidases. Administration of contrykal prevented the development of secondary necrosis, which is evidently associated with a reduction in the activity of the tissue proteolytic enzymes.
Databáze: Supplemental Index
Externí odkaz: