| Autor: |
Nuzhnyi, V. P., Klibaner, M. I., Alaverdyan, A. M. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; September 1977, Vol. 84 Issue: 3 p1229-1233, 5p |
| Abstrakt: |
The intensity of the changes produced by adrenalin in the myocardium of rats adapted to hypoxia was studied after its administration to the intact animal and perfusion of the isolated heart. The changes were revealed by histochemical reactions for succinate dehydrogenase activity and staining for lipids. After intramuscular injection of a cardiotoxic dose of adrenalin (2.0 mg/kg) into adapted rats no damage to the myocardium was found, whereas perfusion of the isolated heart with adrenalin (20 µg/ml) caused the formation of micronecroses of the cardiocytes. However, their volume was statistically significantly smaller than in the isolated heart of intact rats under similar conditions. Differences in the sensitivity of the myocardium in vivo and in vitro indicate that the phenomenon of protection of the myocardium against the harmful effects of adrenalin in rats adapted to hypoxia is manifested at the level of the intact organism. The increase in the resistance of the myocardium itself is probably due to an increase in the power of the metabolic systems during adaptation. |
| Databáze: |
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| Externí odkaz: |
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