| Autor: |
Maizelis, M. Ya., Zabludovskii, A. L. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; September 1976, Vol. 82 Issue: 3 p1327-1329, 3p |
| Abstrakt: |
Incorporation of leucine-14C and methionine-35S into tissue homogenates and protein isolated from various parts of the brain of rats exposed to acute hypoxia in the antenatal period was investigated. Besides active incorporation of amino acids into proteins in other parts of the brain, inhibition of protein synthesis also was observed in certain structures in the experimental animals, especially in the hippocampus. Changes in the uptake of labeled amino acids by the tissue homogenates did not correspond to the level of their incorporation into protein in the individual brain structures. The experimental results points to a disturbance of the intensity of protein metabolism and of the function of the blood-brain barrier in late ontogeny in rats exposed to intrauterine hypoxia. |
| Databáze: |
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