| Autor: |
Valueva, G. V., Kul'chitskii, O. K. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; July 1976, Vol. 82 Issue: 1 p959-962, 4p |
| Abstrakt: |
Age differences in pancreatic insular function and indices of insulin production during sugar loading tests were studied in experiments on rats. Despite hyperinsulinemia and a higher rate of insulin liberation in old animals the utilization of glucose is worsened, evidence of the development of relative insulin insufficiency. Hyperinsultinemia in old animals is accompanied by a decrease in the total blood insulin activity and an increase in the “coefficient of inactivation” of insulin. The development of relative insulin insufficiency with age may be due to both insular and extrapancreatic factors, leading toa reduction in the biological activity of insulin. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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