Some aspects of structural disturbances in the DNP complex when damaged by N-nitroso-N-methylurea

Autor: Gorin, A. I., Serebryanyi, A. M., Antonova, L. V., Atkochyunaite, V. K., Kharitonenkov, I. G., Zoz, N. N., Tseitlin, P. I.
Zdroj: Bulletin of Experimental Biology and Medicine; June 1976, Vol. 81 Issue: 6 p835-838, 4p
Abstrakt: The effect of solubilization of deoxyribonucleoproteins (DNP) in a medium of near-physiological ionic strength after treatment with the mutagen N-nitroso-N-methylurea (NMU) is highly dependent on the NMU concentration. To convert DNP into a soluble state, the critical number of groups in the DNA and protein must evidently be modified. On the basis of data obtained by the circular dichroism method and by viscosimetry it is concluded that after treatment with NMU the DNP complex becomes soluble in solvents with near-physiological ionic strength largely as a result of labilization and dissociation of the DNA-protein bonds.
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