| Autor: |
Evnin, D. N., Kul'berg, A. Ya., Bartova, L. M. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; January 1977, Vol. 83 Issue: 1 p54-56, 3p |
| Abstrakt: |
A comparative study of the adjuvant action of monovalent and bivalent Fab fragments obtained with the aid of pepsin and of the pepsin Fab fragments of normal rabbit IgG showed that their property of intensifying the immune response of rabbits to sheep's red cells is due to the structure of the C-terminal regions of the Fd fragment of the heavy chain. Pepsin F(ab')2 and Fab' fragments stimulated hemagglutinin production and proliferation of antibody-producing cells in the spleen considerably; papain Fab fragments in the same dose had only a very slight effect on the immune response. The ability of fragments obtained with pepsin and papain to stimulate the immune response is inversely proportional to the concentration of pepsin and papain homoreactants in the rabbits' serum. It is postulated on the basis of these findings that the target cells for Fab fragments are lymphocytes with cytophilic homoreactants as their receptors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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