Synthesis and localization of α-fetoprotein during regeneration of the liver in mice

Autor: Éngel'gardt, N. V., Poltoranina, V. S., Lazareva, M. N., Perova, S. D., Gleiberman, A. S.
Zdroj: Bulletin of Experimental Biology and Medicine; October 1976, Vol. 82 Issue: 4 p1563-1568, 6p
Abstrakt: The main site of localization of a-fetoprotein (aFP) in mouse liver regenerating after CCl4 poisoning or partial hepatectomy was in the typical mature hepatocytes that account for not more than a few per cent of the total number of residual hepatocytes. Morphologically they were indistinguishable from the main mass of hepatocytes and they retained on their surface bile capillary antigen. The change in their number and in the brightness of their fluorescence in liver sections corresponded to the dynamics of the aFP level in the animals' serum. During regeneration of the liver in mice aFP is evidently produced mainly by mature hepatocytes.
Databáze: Supplemental Index