| Autor: |
Solov'ev, V. D., Sorokin, A. M., Gutman, N. R. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; December 1975, Vol. 80 Issue: 6 p1456-1458, 3p |
| Abstrakt: |
The use of massive doses of azathioprine under the experimental conditions used had no significant effect on multiplication of type A/PR8 influenza virus and Coxsackie A6 virus. Meanwhile, serum interferon and antibody production was totally suppressed. The blood leukocytes of mice receiving azathioprine did not produce interferonin vitro. The results indicate that a leading role in the pathogenesis of virus infections developing after organ transplantation when massive doses of immunodepressants are used for “rejection crises” is played by disturbance of the formation of the factors of antiviral immunity. The results may be of practical importance for the development of optimal immunodepression programs for organ transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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