A simple method of assessing competitive interaction of reversible inhibitors with cholinesterases

Autor: Tonkopii, V. D., Prozorovskii, V. B., Konstorum, M. G.
Zdroj: Bulletin of Experimental Biology and Medicine; August 1975, Vol. 80 Issue: 2 p993-995, 3p
Abstrakt: A method of determining the degree of competitiveness of interaction of revrsible inhibitors with cholinesterases has been developed. The method is based on comparing I50 values determined by the usual method and on the basis of protecting the enzyme against inhibition by armin. Characteristics of oxazyl, neostigmine, tacrin, mytolon, and galanthamine hydrobromide and iodomethylate obtained by the suggested method are given.
Databáze: Supplemental Index