| Autor: |
Gumulka, S. W., Dinnendahl, V., Schönhöfer, P. S. |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; March 1979, Vol. 306 Issue: 2 p169-172, 4p |
| Abstrakt: |
Naloxone in high doses (60–240 mg/kg i.p.) produced a dose-dependent increase in cerebellar cGMP content of mice. The rise in cGMP content reached its maximum within 5 min and was of short duration. Short-lasting episodes of clonic seizures were noted after 240 mg/kg naloxone. Low doses of naloxone (5–10 mg/kg) had no effect on cerebellar cGMP content, but markedly potentiated the increase in cGMP induced by diazepam, but had only a slight effect on the action of pentobarbital (30 mg/kg i.p.). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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