| Autor: |
Koss, M. C., Christensen, H. D. |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; May 1979, Vol. 307 Issue: 1 p45-50, 6p |
| Abstrakt: |
Intravenous administration of clonidine (1–100 µg/kg) produces a dose-dependent mydriasis in cats by inhibition of parasympathetic tone to the iris. The magnitude of CNS-induced pupillary dilation was similar in both normal anaesthetized cats and in araesthetized preparations pretreated with reserpine (5 mg/kg i.p.) and a-methyl-p-tyrosine (2×300 mg/kg i.p.). Pretreatment reduced the concentrations of noradrenaline, dopamine and serotonin to less than 3% of that control levels in most parts of the CNS in which these amines were measured. Clonidine produced bradycardia in control animals but not in pretreated cats. In amine depleted animals in which only one eye was innervated by the ciliary nerves (parasympathetic), clonidine produced mydriasis only on the innervated side. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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