| Autor: |
Arruda, Jose A. L., Nascimento, Luiz, Arevalo, Gilberto, Baranowski, Robert L., Cubria, Andrew, Carrasquillo, Thomas, Westenfelder, Christof, Kurtzman, Neil A. |
| Zdroj: |
Pflügers Archiv European Journal of Physiology; September 1978, Vol. 376 Issue: 3 p193-199, 7p |
| Abstrakt: |
Bicarbonate reabsorption during bicarbonate loading was measured in rats and in patients with chronic renal failure (CRF) and in normal human subjects. Bicarbonate reabsorption expressed as Tm/GFR was not significantly different between normal and CRF rats despite the fact that fractional chloride excretion was significantly greater (an indication of volume expansion) in CRF rats than in normals. The ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption, a parameter which corrects for the influence of volume on bicarbonate reabsorption, was significantly higher in CRF rats than in normals. In patients with CRF, bicarbonate reabsorption expressed either as Tm/GFR or as the ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption was not different from that of the normal subjects. In patients with CRF, glomerular filtration rate (GFR) varied between 3 and 47 ml/min. The ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption was inversely and significantly related to GFR, i.e. as nephron mass decreases sodium bicarbonate is preferentially reabsorbed over sodium chloride. These data demonstrate that in CRF bicarbonate reabsorption is enhanced relative to that of sodium and chloride in man. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink