| Autor: |
Klee, Manfred R., Faber, Donald S. |
| Zdroj: |
Pflügers Archiv European Journal of Physiology; June 1974, Vol. 346 Issue: 2 p97-106, 10p |
| Abstrakt: |
The effect of mephenesin on the excitability of Aplysia neurons has been investigated with current and voltage clamp techniques. Mephenesin (5 to 10 mM) reduces the action potential amplitude of these neurons and selectively depresses the early inward currents by 30–40%; slightly higher concentrations (10–25 mM) completely block spike generation and the inward current. At the same time, there is relatively little effect on the delayed outward potassium current, the maximal reduction produced by 25 mM being 20%. The complete blockage by mephenesin of the early inward currents which are carried by both sodium and calcium ions contrasts with the actions of other specific blocking agents tested in this preparation, such as tetrodotoxin and cobalt ions, which interact with one ionic channel but not with the other. Finally, 5 mM mephenesin counteracts the generation of convulsive-like multiple discharges observed after strychnine application. This antagonism is attributed to the selective effect of mephenesin on the inward currents. |
| Databáze: |
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| Externí odkaz: |
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