| Autor: |
Kreye, Volker A. W., Pfründer, Dietmar, Theiss, Ursula |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; February 1992, Vol. 345 Issue: 2 p238-243, 6p |
| Abstrakt: |
Tedisamil, a new bradycardic agent with an inhibitory action on K+ channels in cardiac muscle, was found to inhibit in a non-competitive manner the relaxation induced by the K+ channel opener cromakalim in noradrenaline-stimulated helical strips from rabbit aortae. Tedisamil tended to be more potent in this respect than glibenclamide; the latter however competitively antagonized the cromakalim-induced relaxation. In rabbit aorta preloaded with 86Rb as a marker of K+, 10 µmol/l tedisamil inhibited the 86Rb efflux induced by 10 µmol/l cromakalim. — While the 86Rb efflux evoked by depolarization with 100 mmol/l K+ aspartate was inhibited by tedisamil, too, the rise of 86Rb efflux induced by noradrenaline was unaffected by the drug. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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