| Autor: |
Koppen, Chris J., Rodrigues de Miranda, Jaap F., Beld, Arie J., Hermanussen, Marcel W., Lammers, Jan Willem J., Ginneken, Cees A. M. |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; November 1985, Vol. 331 Issue: 2-3 p247-252, 6p |
| Abstrakt: |
Muscarinic receptors in human tracheal smooth muscle were characterized by radioligand binding and functional studies. Specific [3H]-(-)-quinuclidinylbenzilate ([3H]-(-)-QNB) binding to tracheal smooth muscle membranes was reversible, stereoselective and of high affinity (Kd=47±4 pmol/l;RT=920±120 fmol/g tissue). Inhibition of specific [3H]-(-)-QNB binding by the M-1 selective antagonist pirenzepine was found to occur at relative high concentrations classifying the muscarinic receptor population as belonging to the M-2 subclass. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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