| Autor: |
Messmer, K., Lorenz, W., Sunder-Plassmann, L., Kloevekorn, W. P., Hutzel, M. |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; October 1970, Vol. 267 Issue: 5 p433-445, 13p |
| Abstrakt: |
Summary In a series of 133 dogs, 10–20 ml/kg arterial blood were removed and replaced by rapid intravenous infusion of an equivalent volume of various plasma substitutes. Following the infusion of gelatine solutions, an acute fall in arterial blood pressure was observed, but not following the infusion of equal quantities of Dextran 60 or of 0.9% NaCl solution. Measurement of the blood histamine levels as well as the fact that the circulatory effects could be modified by the previous administration of anti-histaminic drugs indicate that the hypotension observed following the rapid infusion of gelatine solutions is due to the release of histamine. Since histamine liberation has also been shown in preliminary studies in man, rapid infusions of gelatine solutions should be avoided in clinical practice, or patients receiving them should be pre-treated with anti-histaminic drugs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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