Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis

Autor:	Himmelfarb, M., Zikk, D., Rapoport, Y., Redianu, C., Shalit, I.
Zdroj:	European Archives of Oto-Rhino-Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS); March 1993, Vol. 250 Issue: Supplement 1 pS15-S17, 3p
Abstrakt:	Summary: Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17–4.34) times higher than the serum concentration and 3.73 (range 1.95–11.00) times higher than the MIC90 of ofloxacin againstPseudomonas aeruginosa.
Databáze:	Supplemental Index
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