Effect of mutations affecting lysyl-tRNALys on the regulation of lysine biosynthesis in Escherichia coli

Autor: Boy, Emmanuelle, Borne, Françoise, Patte, Jean-Claude
Zdroj: Molecular and General Genetics MGG; January 1978, Vol. 159 Issue: 1 p33-38, 6p
Abstrakt: When studying mutants affecting lysyl-tRNA synthetase or tRNALys (hisT, hisW), a lack of correlation is clearly observed between the amount of lysyl-tRNA and the level of derepression of several lysine biosynthetic enzymes. This excludes the possible role of lysyl-tRNA as the specific corepressor of the lysine regulon. However, the level of derepression of DAP-decarboxylase, the last enzyme of the lysine pathway, is very low in the hisT mutant; this indicates that tRNALys is a secondary effector involved in the regulation of the synthesis of this enzyme.
Databáze: Supplemental Index