Polyfunctional macroheterocycles. 4. Synthesis and some chemical transformations of nitrogen- and sulfur-containing crown compounds with exocyclic methoxycarbonyl, cyano, and phenylethyl groups

Autor:	Voronkov, M. G., Knutov, V. I., Butin, M. K.
Zdroj:	Chemistry of Heterocyclic Compounds; February 1992, Vol. 28 Issue: 2 p228-231, 4p
Abstrakt:	The acylation of 1,5-diamino-, 1,5-bis(2-phenylethylamino)-, and 1,5-bis(2-methoxycarbonylethylamino)-3-thiapentanes with adipic and phthalic acid dichlorides, as well as oxalyl chloride, leads to, respectively, 13-,22-, and 18-membered macroheterocydes containing exocyclic methoxycarbonyl andphenylethyl groups. The reduction by LiAlH4 of the endocyclic amido groups and exocyclic ester or cyano groups of some nitrogen- and sulfur-containing crown compounds, which are converted to CH2NR2, CH2OH, and CH2NH2 groups, respectively, was studied. A macrobicyclic system containing endocyclic amido groups was synthesized, and its reduction, which leads to the corresponding CH2NR2 derivative, was investigated.
Databáze:	Supplemental Index
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