Synthesis of several heteryldehydropeptides by the oxazolone method

Autor: Slavinskaya, V. A., Sile, D. É., Katkevich, M., Korchagova, É. Kh., Lipsbergs, I. U., Turovskii, I. V., Lukevits, É.
Zdroj: Chemistry of Heterocyclic Compounds; February 1995, Vol. 31 Issue: 2 p202-205, 4p
Abstrakt: (E)-N-Benzolydehydro-3-(3-pyridyl)-alanyltryptophan was synthesized in 89% yield by the reaction of 2-phenyl-4-(3-pyridylidene)-5(4H)-oxazolone with tryptophan. The reaction of 4-[1-(2-furyliden)ethyl]- and 4-(3-pyridyliden)2-phenyl-5(4H)-oxazolones with alanyltryptophan gives a mixture of theZ andE isomers of the corresponding dehydrotripeptides. Racemization of the alanyl and tryptophan residues was not observed.
Databáze: Supplemental Index