Lactam and acid amide acetals 68. 1-Cyanomethyl-2-pyrrolidone diethylacetal in the synthesis of 7,8-trimethylenepurine derivatives

Autor: Dozorova, E. N., Kadushkin, A. V., Bogdanova, G. A., Solov'eva, N. P., Granik, V. G.
Zdroj: Chemistry of Heterocyclic Compounds; June 1991, Vol. 27 Issue: 6 p590-594, 5p
Abstrakt: 1-Cyanomethyl-2-cyaniminopyrrolidine was synthesized by the reaction of 1-cyanomethyl-2-pyrrolidone diethylacetal with cyanamide. The product undergoes Thorpe—Ziegler cyclization under the influence of sodium ethoxide to give 2-amino-3-cyano-5,6-dihydro-7H-pyrrolo[1,2-a]imidazole, from which 4-amino derivatives of pyrrolo[2,1-f]purine were synthesized.
Databáze: Supplemental Index