Synthesis of 1-(3-halotetrahydro-2-furyl) derivatives of uracil, 5-substituted uracils, and cytosine

Autor: Kaulinya, L. T., Lidak, M. Yu.
Zdroj: Chemistry of Heterocyclic Compounds; January 1987, Vol. 23 Issue: 1 p77-81, 5p
Abstrakt: The cis and trans isomers of 1-(3-halotetrahydro-2-furyl) derivatives of uracil, 5-substituted uracils, and cytosine were obtained by alkylation of 2,4-bis(trimethylsilyl) derivatives of uracil, 5-substituted uracils, and cytosine with 2,3-dihalotetrahydrofurans. 2,3'-Anhydro compounds are also formed in the alkylation of 5-halouracil derivatives. The physicochemical properties of the compounds obtained and the antineoplastic activities of the 5-fluorouracil derivatives were studied.
Databáze: Supplemental Index
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