Intramolecular cyclization of N-phthalyl-β-aryl-β-alanine phenylhydrazide

Autor: Portnov, Yu. N., Zabrodnyaya, V. G., Voronin, V. G., Kost, A. N.
Zdroj: Chemistry of Heterocyclic Compounds; July 1982, Vol. 18 Issue: 7 p703-706, 4p
Abstrakt: The reaction of N-phthalyl-ß-aryl-ß-alanine N'-methyl-N'-phenylhydrazides with phosphorus oxychloride (at~80 °C) is accompanied by further transformations of the initially formed 2-aminoindole derivatives and leads to isoindolo[1',2':2,3]-pyrimido[5,6-b]indole derivatives. Intermediate 2-aminoindoles were isolated at lower reaction temperatures. The hydrolysis of the isoindolo[1',2':2,3]pyrimido [5, 6-b]indole derivatives was studied. The structures of the compounds obtained were established on the basis of the PMR, IR, and UV spectra and the results of elementary analysis.
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