| Autor: |
Smeyne, Richard J., Pickford, Lesley B., Rouse, Robert V., Napieralski, Julie, Goldowitz, Dan |
| Zdroj: |
Anatomy and Embryology; March 1991, Vol. 183 Issue: 3 p213-219, 7p |
| Abstrakt: |
The immunoreactivity in OZ42, a neural cell specific antibody that recognizes premigratory cerebellar granule cells, was examined in early postnatal wild-type and weaver mouse cerebella. We find that the OZ42-positive staining in the external granular layer (EGL) is first seen at postnatal day 1 in the most posterior and ventral aspect of midline cerebellum in the wild-type and heterozygous weaver mouse. By postnatal day 4 strong immunoreactivity is observed in the EGL of all cerebellar lobules. This staining is localized to a band of immunoreactive cells present at the interface of the EGL and the molecular layer (ML). In the homozygous weaver cerebellum, OZ42-positive staining is not seen until post-natal day 3. In the postnatal day 4 weaver cerebellum, immunoreactivity is considerably ligther than in littermate control cerebella, and found throughout the width of the EGL (i.e., not localized to the EGL-ML interface). |
| Databáze: |
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| Externí odkaz: |
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