Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures

Autor: Smit, J. W., Blom, N. R., Luyn, M. J. A., Imhoff, G. W., Halie, M. R.
Zdroj: Annals of Hematology; February 1984, Vol. 48 Issue: 2 p109-115, 7p
Abstrakt: Normal donor peripheral blood mononuclear cells incubated for 24 h with sera from patients with Hodgkin's disease were investigated by electron microscopy for the presence of parallel tubular structures (PTS) and/or amorphous electrondense granules (large granular lymphocytes = LGL). In comparison with normal human serum, 14 out of 29 sera of the patients induced a marked increase in the percentage of LGL. From a limited number of experiments it was likely that this increase is paralleled by an increase in Fc? receptor-bearing cells after the incubation. This serum effect did not show a correlation with the number of Fc? receptor-positive lymphocytes in the peripheral blood of the patients.
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