Relaxant effects of mefloquine on vascular smooth muscle in vitro

Autor: Adegunloye, B. J., Sofola, O. A., Coker, H. A. B.
Zdroj: European Journal of Clinical Pharmacology; August 1993, Vol. 45 Issue: 1 p85-88, 4p
Abstrakt: We have studied the effects of mefloquine on isolated rat aorta. Mefloquine (10-8 to 1.6×10-4 mol · l-1) relaxed aortic rings precontracted with both noradrenaline (10-7 mol·l-1) and potassium chloride (60 mmol·l-1). The mefloquine-induced relaxation was somewhat attenuated by removal of the endothelium.
Databáze: Supplemental Index