Pharmacokinetics of ibuprofen in febrile children

Autor: Nahata, M. C., Durrell, D. E., Powell, D. A., Gupta, N.
Zdroj: European Journal of Clinical Pharmacology; April 1991, Vol. 40 Issue: 4 p427-428, 2p
Abstrakt: Ibuprofen may be an alternative to acetaminophen to control fever in children but little is known about its pharmacokinetics in pediatric patients. We studied 17 patients (age 3–10 yr) with fever; the most prevalent diagnoses were streptococcal pharyngitis and otitis media. Ibuprofen liquid was given as a single dose, 5 mg/kg (9 patients) or 10 mg/kg (8 patients). Multiple blood samples were collected over 8 hours and analyzed by HPLC.
Databáze: Supplemental Index