Acute effect of glipizide on glucose tolerance in obesity and diabetes mellitus (NIDDM)

Autor: Pontiroli, A. E., Perfetti, M. G., Pozza, G.
Zdroj: European Journal of Clinical Pharmacology; January 1991, Vol. 40 Issue: 1 p23-26, 4p
Abstrakt: The attempt has been made to identity the lowest dose of glipizide, a second generation sulphonylurea, capable of improving glucose tolerance in overweight and obese subjects with various degrees of glucose tolerance. Thirty one obese subjects, 12 with non insulin dependent diabetes mellitus (NIDDM), 9 with impaired glucose tolerance (IGT) and 10 with normal glucose tolerance (NGT) each underwent four OGTTS (75 g), at 1 week intervals, after administration in random order of placebo or glipizide 0.5, 1.0 or 2.5 mg 30 min before glucose.
Databáze: Supplemental Index