Effect of methotrexate on the pharmacokinetics and renal excretion of cisplatin

Autor: Preiss, R., Brovtsyn, V. K., Perevodchikova, N. I., Bychkov, M. B., Hüller, H., Belova, L. A., Michailov, P.
Zdroj: European Journal of Clinical Pharmacology; March 1988, Vol. 34 Issue: 2 p139-144, 6p
Abstrakt: The kinetics of platinum in plasma and erythrocytes, and its renal excretion, have been examined in five patients with non-small cell carcinoma of the lung, after treatment with cisplatin 50 mg/m2 (Platidiame) and, three weeks later, a combination of 50 mg/m2 cisplatin and 40 mg/m2 methotrexate. The patients were given 0.9% saline 11 l h prior to drug application.
Databáze: Supplemental Index