Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity

Autor: Ades, P. A., Wolfel, E. E., Hiatt, W. R., Fee, C., Rolfs, R., Brammell, H. L., Horwitz, L. D.
Zdroj: European Journal of Clinical Pharmacology; January 1989, Vol. 36 Issue: 1 p5-10, 6p
Abstrakt: Beta-adrenergic blockade with intrinsic sympathomimetic activity (ISA) causes less depression of resting and submaximal heart rate (HR) than non-ISA beta-blockers. The effects of these drugs on exercise haemodynamics have not been well studied. We evaluated effects of pindolol, propranolol and placebo during rest and steady-state exercise on cardiac output, oxygen consumption, calf blood flow, HR and blood pressure in 18 healthy subjects.
Databáze: Supplemental Index