| Autor: |
Andersson, O., Berglund, G., Descamps, R., Thomis, J. |
| Zdroj: |
European Journal of Clinical Pharmacology; March 1981, Vol. 21 Issue: 2 p87-92, 6p |
| Abstrakt: |
28 patients, aged 35–62 years, with uncomplicated hypertension, entered a double-blind, crossover study, in which the effects of single daily doses of sotalol and metoprolol were compared. Both drugs exerted a clinically useful anti-hypertensive effect as monotherapy, or in combination with a thiazide diuretic. No significant difference in hypotensive effects was noted between the two beta-blocking agents, when the dose was titrated to an optimal clinical effect. Treatment with sotalol and metoprolol was associated with a clinically insignificant increase in serum uric acid concentration. The side-effects observed were few, and in only two cases was therapy discontinued. We regard both sotalol and metoprolol as useful anti-hypertensive drugs. |
| Databáze: |
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| Externí odkaz: |
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