Effect of food on the bioavailability of oxybutynin from a controlled release tablet

Autor: Lukkari, E., Castrèn-Kortekangas, P., Juhakoski, A., Löyttyniemi, E., Aranko, K., Neuvonen, P. J.
Zdroj: European Journal of Clinical Pharmacology; May 1996, Vol. 50 Issue: 3 p221-223, 3p
Abstrakt: Abstract: Objective: The effect of food on the bioavailability of oxybutynin was assessed in a randomised cross-over study in 23 healthy volunteers. A single oral 10 mg dose of a controlled release oxybutynin tablet was administered after a high fat breakfast and to fasting subjects. The AUC, Cmax, tmax, t1/2 and MRT of oxybutynin and its active metabolite N-desethyloxybutynin were determined. Results: Breakfast did not change the AUC of oxybutynin but increased the AUC of N-desethyloxybutynin by about 20% . The Cmax of oxybutynin and N-desethyl oxybutynin were two-fold higher when the drug was administered after breakfast compared to the fasting state. Conclusion: Breakfast significantly reduced the MRT of oxybutynin and N-desethyloxybutynin.
Databáze: Supplemental Index
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