| Autor: |
Reynolds, C. N., Wilson, K., Burnett, D. |
| Zdroj: |
European Journal of Clinical Pharmacology; July 1978, Vol. 13 Issue: 4 p285-289, 5p |
| Abstrakt: |
The urinary excretion of fiveC-monohydroxy metabolites and theN-oxide of methaqualone has been measured in a group of eleven geriatric patients aged 71–90 years. The total excretion of the six metabolites in 24 h after the oral administration of a single dose was approximately one-half of that in a group of young healthy adults. The relative importance of the six metabolites was 4'-hydroxy »N-oxide> 2'-hydroxymethyl = 3'-hydroxy > 6-hydroxy = 2-hydroxymethyl which was the same order as that in young adults. The ratio ofC-toN-oxidation was also the same in the two groups. There was no impairment of conjugation of theC-hydroxy metabolites with glucuronic acid in the geriatric group but there was greater interindividual variation in metabolite excretion. There was also evidence for delayed metabolism in the geriatric patients. |
| Databáze: |
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| Externí odkaz: |
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