| Abstrakt: |
Serum thyrotropin (TSH) and growth hormone (GH) were measured in 24 women and 25 men with juvenile diabetes and in comparable normals. Samples were obtained in the postprandial state at 11 a.m., during a 24 h period of daily life and after thyrotropin releasing hormone (TRH) stimulation. The diurnal TSH rhythm in the diabetics was similar to that found in normals. The TSH values at the nadir of the diurnal TSH rhythm (11 a. m.) were identical in diabetics and normals; in addition there was no difference in the TSH response to TRH. No sex dependent difference of the basal TSH level or of TSH response to TRH was present. Serum GH was higher in women than in men, and higher in diabetics than in normals. The study indicates that diabetes mellitus is not likely to be a disease accompanied by a generalized hypo-thalamic dysfunction. |
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