| Autor: |
Schouten, Teunis J., Abreu, Ronney A., Schretlen, Egbert D. A. M., Leeuwen, Marinella B., Baal, John M., Vaan, Gérard A. M. |
| Zdroj: |
Journal of Cancer Research and Clinical Oncology; September 1985, Vol. 110 Issue: 2 p115-118, 4p |
| Abstrakt: |
6-Thioguanine (6TG) is poorly absorbed after oral administration. Bolus injections of 6TG result in high peak concentrations with relatively shortlived plasma concentrations. In vitro studies have shown the importance of prolonged exposure to 6TG. Therefore we administered 6TG by infusion at a dose rate of 2 mg/h over 2 h. In three goats we determined the plasma concentration-time curves of 6TG and its riboside (6TGR). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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