Amoxapine and amitriptyline

Autor: McNair, Douglas M., Kahn, Richard J., Frankenthaler, Laura M., Faldetta, Linda L.
Zdroj: Psychopharmacology; May 1984, Vol. 83 Issue: 2 p129-133, 5p
Abstrakt: Speed of onset of antidepressant effect was studied in 20 depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline. In counterbalanced order, each patient had 2 periods of 3 weeks on active agent interspersed with 2 similar periods of placebo control. On daily and weekly self-ratings, amoxapine was found to reduce symptoms significantly more rapidly than amitriptyline. Psychiatrist-ratings were consonant with selfreports.
Databáze: Supplemental Index