| Autor: |
Swedberg, M. D. B., Loman, P., Järbe, T. U. C. |
| Zdroj: |
Psychopharmacology; January 1978, Vol. 59 Issue: 2 p165-170, 6p |
| Abstrakt: |
Chlormethiazole (CMZ, 80 mg/kg) was used as a discriminative stimulus in gerbils; i.e., the presence or absence of certain effects of the drug controlled the choice behavior (left or right turn) of the animals trained to escape electric shocks in a T-maze. Substitution tests with pentobarbital (5–25 mg/kg) and ethanol (0.5–2.5 g/kg) indicated at least a partial similarity in the stimulus effects of CMZ and the two other drugs. The CMZ stimulus was attenuated by 30 mg/kg of the analeptic bemegride (BMG). In Experiment II, gerbils were trained to discriminate CMZ (80 mg/kg) from either of two doses of ethanol (1.5 or 2.0 g/kg). The acquisition rates for the latter groups appeared some-what slower than that noted for the gerbils in Experiment I, although only one measure significantly differentiated the groups. A qualitative difference is proposed as the basis for the discrimination between CMZ and ethanol. Open-field (O-F) tests 5 min after injections of CMZ (80 mg/kg) depressed both horizontal (ambulation) and vertical (rearing) activity, effects found to be counteracted by BMG (30 mg/kg) during the initial segment of the O-F testing. However, a second O-F test carried out 60 min after injections showed that the behaviors of the gerbils treated with the combination of CMZ and BMG were now markedly depressed. The effects of the drug combination on colonic temperature of the gerbils showed similar changes over time; i.e., the mixture of BMG and CMZ resulted in a normal colonic temperature response 5 min postinjection (p.i.), after which a marked drop of temperature followed at the recordings 60 min p.i. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink