| Autor: |
Pijnenburg, A. J. J., Honig, W. M. M., Rossum, J. M. |
| Zdroj: |
Psychopharmacology; January 1975, Vol. 41 Issue: 2 p87-95, 9p |
| Abstrakt: |
The effect of intracerebral administration of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d-amphetamine sulfate in rats was investigated. Injection of low doses of the dopamine antagonist haloperidol (2.5 ?g and 5 ?g) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d-amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or the beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the same doses of haloperidol into the caudate nucleus did not inhibit the d-amphetamine induced locomotor activity, in contrast to the effects seen following injection into the nucleus accumbens. |
| Databáze: |
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| Externí odkaz: |
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