Doxepin and amitriptyline-perphenazine in mixed anxious-depressed neurotic outpatients: A collaborative controlled study

Autor: Rickels, Karl, Hutchison, James C., Weise, Charles C., Csanalosi, Irma, Chung, Hack R., Case, Warren G.
Zdroj: Psychopharmacology; December 1972, Vol. 23 Issue: 4 p305-318, 14p
Abstrakt: Doxepin was compared to the combination of amitriptyline-perphenazine in a double-blind controlled study conducted with 100 clinic, general practice, and private psychiatric practice outpatients diagnosed as suffering from a mixed anxiety-depressive reaction. The relatively few statistically significant differences found in the study indicated amitriptyline-perphenazine to be more effective than doxepin (main drug effects), general practice patients to improve the most and private psychiatric patients the least (main population effects), and clinic patients to respond better to doxepin, while general practice and private psychiatric patients improved most with the drug combination (drug×population interaction effects).
Databáze: Supplemental Index