| Autor: |
Boggan, William O., Freedman, Daniel X., Lovell, Richard A., Schlesinger, Kurt |
| Zdroj: |
Psychopharmacology; March 1971, Vol. 20 Issue: 1 p48-56, 9p |
| Abstrakt: |
A genetically heterogeneous (HS) group of mice and a highly inbred strain of mice (C57BL/6) were both shown to become highly susceptible to audiogenic seizures after exposure to acoustic stimulation (priming). In heterogeneous mice the optimal age for priming was 18 days with a test-retest interval of 48 hours. The optimal test-retest interval in C57BL/6 mice primed at 20 days of age was 8 days. One second of priming was found effective in enhancing seizure susceptibility. Drugs known to alter steady state levels of biogenic amines and to change responses of mice genetically predisposed to audiogenic seizures were found to be effective in altering seizure susceptibility from priming, but not effective in altering the priming itself. |
| Databáze: |
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