Synthesis of enkephalins by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone

Autor: Grigor'ev, E., Chernova, S.
Zdroj: Chemistry of Natural Compounds; July 1989, Vol. 25 Issue: 4 p468-474, 7p
Abstrakt: Leucine- and methionine-enkephalins have been synthesized by the successive growth of the peptide chain from the C-end by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone with yields of 90 and 70%, respectively, calculated on the initial C-terminal amino acid. Polystyrene with 2% of divinylbenzene was used as the polymeric matrix. Using the synthesis of methionine-enkephalin as an example, the possibility has been shown of using polymeric activated esters for the synthesis of peptides with a free carboxy group.
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