| Autor: |
Tsytovich, A. V., Oretskaya, T. S., Dolinnaya, N. G., Sokolova, N. I., Shabarova, Z. A. |
| Zdroj: |
Chemistry of Natural Compounds; May 1987, Vol. 23 Issue: 3 p349-352, 4p |
| Abstrakt: |
To study the substrate specificity of T4 DNA ligase a series of short DNA duplexes each of which contains in the ligation site a nucleoside with a modified sugar residue is proposed. The synthesis has been performed on previously undescribed mixed dinucleoside phosphates containing deoxycytidine and one of the following modified nucleosides: deoxyxylothymidine and xylo-, lyxo-, and arabinouridines. By the phosphotriester method in solution, using the above-mentioned dinucleoside phosphates, nonanucleotides containing at the 3'-end nucleosides with inverted configurations at the carbon atoms in positions 2' and 3' have been obtained. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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